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REVIEW ARTICLE
Year : 2017  |  Volume : 3  |  Issue : 1  |  Page : 41-45

Prolotherapy: From glorious past to promising future


1 Consultant, Department of Anesthesiology and Pain Medicine, Meditrina Institute of Medical Sciences, Nagpur, Maharashtra, India
2 Associate Professor, Department of Anesthesiology and Pain Medicine, Neta Ji Subhash Chandra Bose Medical College & Hospital, Jabalpur, Madhya Pradesh, India

Correspondence Address:
Neelesh K Mathankar
Consultant, Department of Anesthesiology and Pain Medicine, Meditrina Institute of Medical Sciences, Nagpur, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.5005/jp-journals-10046-0064

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Prolotherapy, a nonsurgical regenerative injection therapy, is becoming increasingly popular among the pain physicians as well as patients. The current theory suggests that the prolotherapy mimics the natural healing process of the body by initiating a local inflammatory cascade, which triggers the release of growth factors and collagen deposition. Although the clinical literature on prolotherapy had been published since last 80 years, the quality, number, and research have increased since the 1990s. The growing body of evidences suggests its use in osteoarthritis, low back pain, and tendinopathies. With recent advances in stem cell therapy and regenerative medicine, prolotherapy will play a greater role in the treatment of chronic degenerative conditions and sports injuries.


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